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VITILIGO

CLASSIFICATION

two broad types are accepted, viz.
Depending on the aetiopathogenesis, vitiligo can be classified as:

1. 2. 3.	Immune (progressive vitiligo), Neural (segmental/dermatomal), and Chemical (contact).
Aetiopathogenesis
	Immune Hypothesis Neural Hypothesis Autotoxic, Self-destructive or Free Radical Hypothesis Melanocytes Growth Factors Reduction Hypothesis
Management
Medicinal Treatment
(A) Photochemotherapeutic approaches with

ii) Psoralen compounds
ii) Khellin
iii)Phenylalanine
iv) Miscellaneous agents of dubious value
(a) Sulphonylurea compounds
(b) Phenothiazine derivatives
(c) Griseofulvin
(d) Clofazine
(e) Polypodium leucotomos

(B)	Non-photochemotherapeutic approaches with : ii) Corticosteroids ii) Quinoline compounds iii)Cyclophosphamide iv) Fluouracil v) Clofazimine vi) DDS vii) Nialamide viii) Placental extract
(C) (D) (E)	Systemic non-melanin colouring agent - Can-thaxanthin. Other drugs Topical corticosteroids Hydrocortisone acetate Moderately potent Alchlometasone dipropionate Clobetason butyrate Fluocinolone acetonide Fluocortin butylester Flumetason pivalate Triamciolone acetonide

Potent

	Amcinonide Betamethasone valerate/dipropionate/benzoate Budesonide Desoximethasone Diflucortolone valerate Fluocinonide Fluticasone Very potent Beclomethasone dipropionate Clobetason propionate.
Surgical Treatment Surgical approaches comprise:
(i) (ii) (iii) (iv)	Thin Thiersch grafting Epidermal grafting Minigrafting Transplantations of in vitro cultured epidermis bearing melanocytes.

Cosmetic Camouflaging

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